1033129-97-3Relevant academic research and scientific papers
Enantioselective Deuteration of β-Substituted α,β-Unsaturated Esters by Rhodium-1,2-Bis(2,5-diphenylphospholano)ethane
Lethu, Sébastien,Ano, Hikaru,Murata, Michio,Matsuoka, Shigeru
, p. 235 - 239 (2018/01/27)
We report an efficient method for the synthesis of a chiral C-CHD-CHD-C unit in threo form, which enables the asymmetric conformational analysis of straight alkyl chains. The vicinal dideuterated compound was constructed by enantioselective catalytic deut
Asymmetric synthesis of vicinal amino alcohols: Xestoaminol C, sphinganine and sphingosine
Abraham, Elin,Davies, Stephen G.,Millican, Nicholas L.,Nicholson, Rebecca L.,Roberts, Paul M.,Smith, Andrew D.
supporting information; experimental part, p. 1655 - 1664 (2008/10/09)
The highly diastereoselective anti-aminohydroxylation of α,β-unsaturated esters, via conjugate addition of lithium (S)-N-benzyl-N-(α-methylbenzyl)amide and subsequent in situ enolate oxidation with (+)-(camphorsulfonyl)oxaziridine, has been used as the key step in the asymmetric synthesis of N,O-diacetyl xestoaminol C (41% yield over 8 steps), N,O,O-triacetyl sphinganine (30% yield over 8 steps) and N,O,O-triacetyl sphingosine (30% yield over 7 steps). The Royal Society of Chemistry 2008.
