103317-59-5Relevant articles and documents
A coccidian preparation method
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Paragraph 0027; 0048-0049, (2018/09/02)
The invention relates to a preparation method for diclazuril. A document reports that the synthesis of diclazuril is carried out in a such way that 2,6-dichloro-para-nitroaniline or 3,4,5-trichloronitrobenzene is used as an initial raw material and is subjected to diazotization reaction, substitution reaction, reduction reaction and the like to prepare a common intermediate 3. The existing process has many steps and is low in overall yield so that the costs of diclazuril raw materials and preparation stay at a high level. The invention provides a synthetic process of diclazuril. Particularly, the synthetic process comprises the steps that an intermediate 4 is prepared by performing reaction on the intermediate 3 and sodium nitrite by means of reduction and is subjected to cyclization and ring enlargement to obtain a product. In the route, a column chromatography means is not adopted; therefore, the process is short in the reaction steps and is suitable for industrial production.
Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
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, (2008/06/13)
The present invention is related with α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitriles which are effective in destructing or preventing the growth of Protozoa in subjects suffering from such Protozoa.