1033202-14-0

Basic information

• Product Name: 3-fluoro-5-nitropyridin-2-ol
• Synonyms: 3-Fluoro-5-nitro-1H-pyridin-2-one;3-FLUORO-2-HYDROXY-5-NITROPYRIDINE
• CAS NO: 1033202-14-0
• Molecular Formula: C₅H₃FN₂O₃
• Molecular Weight: 158.0873232
• Mol File: 1033202-14-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 244.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.00±0.10(Predicted)
• CAS DataBase Reference: 3-fluoro-5-nitropyridin-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-fluoro-5-nitropyridin-2-ol(1033202-14-0)
• EPA Substance Registry System: 3-fluoro-5-nitropyridin-2-ol(1033202-14-0)

Safety Data

• Hazardous Substances Data: 1033202-14-0(Hazardous Substances Data)

Usage

General Description

3-Fluoro-5-nitropyridin-2-ol is a chemical compound with the molecular formula C5H3FN2O3. It is a nitro-substituted pyridine derivative that contains a fluorine atom and a hydroxyl group. 3-fluoro-5-nitropyridin-2-ol is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic chemicals. It is also used as a reagent in organic synthesis and can be found in some research and development laboratories for its unique chemical properties. The presence of a fluorine atom and a nitro group in its structure make 3-fluoro-5-nitropyridin-2-ol a versatile compound with potential applications in various industries. However, it is important to handle this compound with care due to its potential hazards and health risks.

Upstream product

• 1547-29-1 3-fluoro-1,2-dihydropyridin-2-one 

Downstream Products

• 1079179-12-6 2-chloro-3-fluoro-5-nitro-pyridine 
• 1419597-57-1 1-((1-(3-chlorophenyl)-3-cyclopropyl-1H-pyrazol-5-yl)methyl)-3-(5-fluoro-6-(2-(methylsulfonyl)ethyl)pyridin-3-yl)urea 
• 1419602-65-5 phenyl 5-fluoro-6-(2-(methylsulfonyl)ethyl)pyridin-3-ylcarbamate 

Relevant articles and documents

Synthesis method of 3-fluoro-5-nitrobenzaldehyde

The invention belongs to the technical field of medical intermediates, and particularly relates to a synthetic method of 3-fluorine -5-nitrobenzaldehyde. A compound A is used as an initial raw material, a compound B is generated in a concentrated sulfuric

Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway

The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use in the clinic and the drug-drug interactions with rifampicin have prompted research efforts towards identifying alternative ATP synthesis inhibitors with differentiated mechanisms of action. A biochemical assay was employed to screen AstraZeneca's corporate compound collection to identify the inhibitors of mycobacterial ATP synthesis. The high-throughput screening resulted in the identification of 2,4-diaminoquinazolines as inhibitors of the ATP synthesis pathway. A structure-activity relationship for the quinazolines was established and the knowledge was utilized to morph the quinazoline core into quinoline and pyrazolopyrimidine to expand the scope of chemical diversity. The morphed scaffolds exhibited a 10-fold improvement in enzyme potency and over 100-fold improvement in selectivity against inhibition of mammalian mitochondrial ATP synthesis. These novel compounds were bactericidal and demonstrated growth retardation of Mycobacterium tuberculosis in the acute mouse model of tuberculosis infection.