103321-06-8Relevant articles and documents
Surface properties of sulfur- and ether-linked phosphonolipids with and without purified hydrophobic lung surfactant proteins
Chang, Yusuo,Wang, Zhengdong,Schwan, Adrian L.,Wang, Zhongyi,Holm, Bruce A.,Baatz, John E.,Notter, Robert H.
, p. 77 - 93 (2005)
Two novel C16:0 sulfur-linked phosphonolipids (S-lipid and SO 2-lipid) and two ether-linked phosphonolipids (C16:0 DEPN-8 and C16:1 UnDEPN-8) were studied for surface behavior alone and in mixtures with purified bovine lung surfactant proteins
Synthesis and interfacial behavior of sulfur-containing analogs of lung surfactant dipalmitoyl phosphatidylcholine
Chang, Yusuo,Wang, Zhengdong,Notter, Robert H.,Wang, Zhongyi,Qu, Long,Schwan, Adrian L.
, p. 5983 - 5986 (2004)
The synthesis and potential of lipids 2 and 3 to act as lung surfactants is reported. Synthesis methods and initial surface property characterizations are reported for two sulfur-containing phosphonolipids related structurally to dipalmitoyl phosphatidylc
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect
Sevrain, Charlotte M.,Fontaine, Delphine,Bauduin, Alicia,Guéguinou, Maxime,Zhang, Bei Li,Chant?me, Aurélie,Mahéo, Karine,Pasqualin, C?me,Maupoil, Véronique,Couthon, Hélène,Vandier, Christophe,Jaffrès, Paul-Alain
, p. 2753 - 2766 (2021/04/07)
The modulation of SK3 ion channels can be efficiently and selectively achieved by using the amphiphilic compound Ohmline (a glyco-glycero-ether-lipid). We report herein a series of Ohmline analogues featuring the replacement of one ether function by a thi
Nucleoside conjugates. 11. Synthesis and antitumor activity of 1-β-D-arabinofuranosylcytosine and cytidine conjugates of thioether lipids
Il Hong,Kirisits,Nechaev,Buchheit,West
, p. 1380 - 1386 (2007/10/02)
Five 1-β-D-arabinofuranosylcytosine conjugates and two cytidine conjugates of thioether lipids (1-S-alkylthioglycerols) linked by a pyrophosphate diester bond have been prepared and their antitumor activity against an ara-C2 sensitive (L1210/0)
Synthesis and biological activity of novel quaternary ammonium derivatives of alkylglycerols and potent inhibitors of protein kinase C
Marasco Jr.,Piantadosi,Meyer,Morris-Natschke,Ishaq,Small,Daniel
, p. 985 - 992 (2007/10/02)
Alyklglycerols such as rac-1-O-octadecyl-2-O-methylglycerophosphochocholine (Et-18-OMe) have shown an inhibitory effect on the metastasis and growth of various cancer cell lines. Alkyl phospholipids have been shown to accumulate at the surface in several cell lines, the selectivity of which is still not clearly understood. A consequence of this action may lead to the inhibition of cell membrane related protein kinase C (PKC). The goal of this research was to develop ether lipid inhibitors of PKC to augment antineoplastic activity. This led to the synthesis and in vitro testing of a series of novel quaternary ammonium derivatives of alkylglycerols. The biological testing of these analogues on PKC stimulated with rac-1-O-oleoyl-2-O-acetylglycerol showed several analogues with inhibition comparable to that of Et-18-OMe.
Synthesis of Sulfur Analogues of Alkyl Lysophospholipid and Neoplastic Cell Growth Inhibitory Properties
Morris-Natschke, Susan,Surles, Jefferson R.,Daniel, Larry W.,Berens, Michael E.,Modest, Edward J.,Piantadosi, Claude
, p. 2114 - 2117 (2007/10/02)
Five sulfur-containing phospholipid analogues (compounds 1-5) of alkyl lysophospholipid (1-O-alkyl-2-O-methyl-rac-glycero-3-phosphocholine, ALP) were synthesized and tested for inhibition of neoplastic cell proliferation with two human ovarian carcinoma cell lines in a clonogenic assay and with the HL-60 promyelocytic leukemia cell line.Compared with 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (ET-18-OMe), the most active reference analogue, these thio analogues are at least as active against HL-60 cells, and the 1-S-hexadecyl-2-O-ethyl analogue (2) is twice as active in the clonogenic assays.
