103322-29-8

Basic information

• Product Name: pyroglutamyl-asparaginamide
• Synonyms: pyroglutamyl-asparaginamide
• CAS NO: 103322-29-8
• Molecular Formula: C9H14 N4 O4
• Molecular Weight: 242.2319
• Mol File: 103322-29-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 841.3°Cat760mmHg
• Flash Point: 462.6°C
• Appearance: /
• Density: 1.401g/cm³
• Vapor Pressure: 1.55E-28mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: pyroglutamyl-asparaginamide(CAS DataBase Reference)
• NIST Chemistry Reference: pyroglutamyl-asparaginamide(103322-29-8)
• EPA Substance Registry System: pyroglutamyl-asparaginamide(103322-29-8)

Safety Data

• Hazardous Substances Data: 103322-29-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H14N4O4/c10-6(14)3-5(8(11)16)13-9(17)4-1-2-7(15)12-4/h4-5H,1-3H2,(H2,10,14)(H2,11,16)(H,12,15)(H,13,17)/t4-,5-/m0/s1

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 28990-85-4 pentachlorophenyl ester of L-pyroglutamic acid 
• 57471-69-9 L-asparaginamide hydrochloride 
• 114967-94-1 (S)-pyroglutamyl-(S)-aspartic acid diethyl ester 
• 16748-73-5 L-asparagine amide 

Relevant articles and documents

POSSIBLE STRUCTURO-FUNCTIONAL ASSOCIATION OF PYRACETAM AND VASOPRESSIN

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SYNTHESIS OF PYROGLUTAMYLASPARAGINE AMIDE DIPEPTIDE FRAGMENT OF VASOPRESSIN, AND THE STEREOSELECTIVITY OF ITS MNEMIC EFFECT

Four diastereomers of pGlu-Asn-NH2 were synthesized.They were considered on one hand as a peptide analogue of piracetam, and on the other as an N-terminal fragment of the major metabolite of vasopressin 4, Cyt6>AVP(4-9).The influence of these diastereomers on the memory of rats was studied in the passive avoidance conditioned reflex test.It was shown that L-pGlu-L-Asn-NH2 and D-pGlu-D-Asn-NH2 in the same doses facilitate the training of rats; D-pGlu-D-Asn-NH2 is inactive, and L-pGlu-D-Asn-NH2 has amnestic activity.These facts suggest a receptor mechanism for the action of the dipeptide pGlu-Asn-NH2 and are the basis for a hypothesis for the topology of the nootropic receptor binding site.