1033224-60-0

Basic information

• Product Name: 1-Phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide
• Synonyms: 1-Phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide
• CAS NO: 1033224-60-0
• Molecular Formula: C₁₂H₁₀N₂O₂S
• Molecular Weight: 246.285
• Mol File: 1033224-60-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(1033224-60-0)
• EPA Substance Registry System: 1-Phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(1033224-60-0)

Safety Data

• Hazardous Substances Data: 1033224-60-0(Hazardous Substances Data)

Usage

Type of drug

Nonsteroidal anti-inflammatory drug (NSAID)

Function

Relieves pain and reduces inflammation in conditions such as arthritis and acute injury

Mechanism of action

Inhibits the production of certain chemicals in the body that cause pain and inflammation

Available forms

Oral tablets, topical gels, and suppositories

Common uses

Management of pain and inflammation associated with conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis

Potential side effects

Gastrointestinal irritation, impaired kidney function, and an increased risk of cardiovascular events

Caution

Should be used cautiously and under the guidance of a healthcare professional.

Upstream product

• 534-85-0 N-phenyl-1,2-benzenediamine 

Downstream Products

• 1033224-89-3 1-(4-bromobutyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033226-35-5 1-(2-bromoethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033225-72-7 tert-butyl 2-((2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl)methyl)morpholine-4-carboxylate 
• 1033226-28-6 tert-butyl 3-(2-(2,2-dioxido-3-phenyl-2,1,3-benzothiadiazol-1(3H)-yl)ethyl)piperidine-1-carboxylate 
• 1033221-98-5 1-phenyl-3-(2-piperidin-3-ylethyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1039033-19-6 C₂₃H₂₉N₃O₅S 
• 1033221-41-8 1-[(4-methylmorpholin-2-yl)methyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033221-38-3 1-[(2S)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033221-35-0 1-[(2R)-morpholin-2-ylmethyl]-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 
• 1033221-32-7 1-(morpholin-2-ylmethyl)-3-phenyl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 

Relevant articles and documents

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3 H)-yl]-1-(methylamino)butan-2- ols (WYE-103231)

Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol- 1(3H)-yl]-1-(methylamino)butan-2-ols which are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound S-17b (WYE-103231) had low nanomolar hNET potency (IC50 = 1.2 nM) and excellent selectivity for hNET over hSERT (>1600-fold) and hDAT (>600-fold). S-17b additionally had a good pharmacokinetic profile and demonstrated oral efficacy in rat models of ovariectomized-induced thermoregulatory dysfunction and morphine dependent flush as well as the hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain.