1033224-62-2 Usage
General Description
1-(4-Fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide is a chemical compound with the molecular formula C13H9FNO2S. 1-(4-Fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide belongs to the class of benzothiadiazole derivatives, which are known for their potential applications in materials science and pharmaceutical research. It is a heterocyclic compound containing a benzene ring fused to a 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide ring, with a fluorophenyl substituent at the 1-position. These types of compounds have been studied for their potential as organic semiconductors and light-emitting materials, as well as for their biological activities. The specific properties and applications of 1-(4-Fluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide may vary depending on its chemical structure and functional groups, and further research is needed to fully understand its potential.
Check Digit Verification of cas no
The CAS Registry Mumber 1033224-62-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,2,2 and 4 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1033224-62:
(9*1)+(8*0)+(7*3)+(6*3)+(5*2)+(4*2)+(3*4)+(2*6)+(1*2)=92
92 % 10 = 2
So 1033224-62-2 is a valid CAS Registry Number.
1033224-62-2Relevant articles and documents
Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3 H)-yl]-1-(methylamino)butan-2- ols (WYE-103231)
O'Neill, David J.,Adedoyin, Adedayo,Alfinito, Peter D.,Bray, Jenifer A.,Cosmi, Scott,Deecher, Darlene C.,Fensome, Andrew,Harrison, Jim,Leventhal, Liza,Mann, Charles,McComas, Casey C.,Sullivan, Nicole R.,Spangler, Taylor B.,Uveges, Albert J.,Trybulski, Eugene J.,Whiteside, Garth T.,Zhang, Puwen
experimental part, p. 4511 - 4521 (2010/08/20)
Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol- 1(3H)-yl]-1-(methylamino)butan-2-ols which are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound S-17b (WYE-103231) had low nanomolar hNET potency (IC50 = 1.2 nM) and excellent selectivity for hNET over hSERT (>1600-fold) and hDAT (>600-fold). S-17b additionally had a good pharmacokinetic profile and demonstrated oral efficacy in rat models of ovariectomized-induced thermoregulatory dysfunction and morphine dependent flush as well as the hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain.
