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1033224-87-1

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1033224-87-1 Usage

General Description

1-(3-Methoxyphenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide, also known as bendroflumethiazide, is a medication primarily used to treat high blood pressure and swelling due to congestive heart failure. It belongs to the thiazide diuretic class of drugs, which work by increasing the amount of water and salt expelled from the body in the urine. This helps to lower blood pressure and reduce swelling. Bendroflumethiazide is typically taken orally, and its effects can be seen within a few hours of administration. It is generally well-tolerated, but like all medications, it may cause side effects such as dizziness, muscle cramps, and low potassium levels. It is important to take this medication exactly as prescribed and to follow up with a healthcare provider regularly while taking it.

Check Digit Verification of cas no

The CAS Registry Mumber 1033224-87-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,2,2 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1033224-87:
(9*1)+(8*0)+(7*3)+(6*3)+(5*2)+(4*2)+(3*4)+(2*8)+(1*7)=101
101 % 10 = 1
So 1033224-87-1 is a valid CAS Registry Number.

1033224-87-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3-methoxyphenyl)-1H-2λ<sup>6</sup>,1,3-benzothiadiazole 2,2-dioxide

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1033224-87-1 SDS

1033224-87-1Downstream Products

1033224-87-1Relevant articles and documents

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3 H)-yl]-1-(methylamino)butan-2- ols (WYE-103231)

O'Neill, David J.,Adedoyin, Adedayo,Alfinito, Peter D.,Bray, Jenifer A.,Cosmi, Scott,Deecher, Darlene C.,Fensome, Andrew,Harrison, Jim,Leventhal, Liza,Mann, Charles,McComas, Casey C.,Sullivan, Nicole R.,Spangler, Taylor B.,Uveges, Albert J.,Trybulski, Eugene J.,Whiteside, Garth T.,Zhang, Puwen

experimental part, p. 4511 - 4521 (2010/08/20)

Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol- 1(3H)-yl]-1-(methylamino)butan-2-ols which are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound S-17b (WYE-103231) had low nanomolar hNET potency (IC50 = 1.2 nM) and excellent selectivity for hNET over hSERT (>1600-fold) and hDAT (>600-fold). S-17b additionally had a good pharmacokinetic profile and demonstrated oral efficacy in rat models of ovariectomized-induced thermoregulatory dysfunction and morphine dependent flush as well as the hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain.

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