1033225-66-9

Basic information

• Product Name: 1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide
• Synonyms: 1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide
• CAS NO: 1033225-66-9
• Molecular Formula: C₁₂H₉ClN₂O₂S
• Molecular Weight: 280.73006
• Mol File: 1033225-66-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(1033225-66-9)
• EPA Substance Registry System: 1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide(1033225-66-9)

Safety Data

• Hazardous Substances Data: 1033225-66-9(Hazardous Substances Data)

Usage

General Description

1-(2-Chlorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide, also known as dyclonine, is a local anesthetic and analgesic medication commonly used to relieve pain and discomfort associated with minor skin irritations, sore throat, and sunburn. It works by blocking the conduction of nerve impulses and reducing the sensitivity of nerve endings in the skin, resulting in temporary numbness and pain relief. Dyclonine is often found in over-the-counter topical products such as throat lozenges, mouthwashes, and skin creams, providing fast and effective relief for various minor ailments. It is generally considered safe and well-tolerated when used as directed, but like all medications, dyclonine may cause adverse reactions or interactions in some individuals and should be used with caution.

Upstream product

• 74864-94-1 N₁-(2-chlorophenyl)benzene-1,2-diamine 

Relevant articles and documents

Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-Aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3 H)-yl]-1-(methylamino)butan-2- ols (WYE-103231)

Structural modification of a virtual screening hit led to the identification of a new series of 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol- 1(3H)-yl]-1-(methylamino)butan-2-ols which are potent and selective inhibitors of the norepinephrine transporter over both the serotonin and dopamine transporters. One representative compound S-17b (WYE-103231) had low nanomolar hNET potency (IC50 = 1.2 nM) and excellent selectivity for hNET over hSERT (>1600-fold) and hDAT (>600-fold). S-17b additionally had a good pharmacokinetic profile and demonstrated oral efficacy in rat models of ovariectomized-induced thermoregulatory dysfunction and morphine dependent flush as well as the hot plate and spinal nerve ligation (SNL) models of acute and neuropathic pain.