1033227-40-5

Basic information

• Product Name: 1-N-(2,4-difluorophenyl)benzene-1,2-diamine
• Synonyms: 2-N-(2,4-difluorophenyl)benzene-1,2-diamine;1-N-(2,4-difluorophenyl)benzene-1,2-diamine
• CAS NO: 1033227-40-5
• Molecular Formula: C₁₂H₁₀F₂N₂
• Molecular Weight: 220.22
• Mol File: 1033227-40-5.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-N-(2,4-difluorophenyl)benzene-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-(2,4-difluorophenyl)benzene-1,2-diamine(1033227-40-5)
• EPA Substance Registry System: 1-N-(2,4-difluorophenyl)benzene-1,2-diamine(1033227-40-5)

Safety Data

• Hazardous Substances Data: 1033227-40-5(Hazardous Substances Data)

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 367-25-9 2,4-difluorophenylamine 
• 500302-20-5 2,4-difluoro-N-(2-nitrophenyl)aniline 

Downstream Products

• 1033226-49-1 1-(2,4-difluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide 

Relevant articles and documents

FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST

The present invention relates to fused cyclic urea derivatives which have antagonistic activities against CRHR1 and/or CRHR2, and which are useful in the treatment or prevention of disorders and diseases in which CRHR1 and/or CRHR2 is involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CRHR1 and/or CRHR2 is involved.

Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modi?ed scaffold as potent antifungal agents

Twenty-seven novel pyrazole carboxamides with diarylamine-modi?ed scaffold were designed, synthesized and characterized in detail via 1H NMR, 13C NMR, IR and ESI-HRMS. Preliminary bioassays showed that some of the target compounds exhibited good antifungal activity against Rhizoctonia solani, Rhizoctonia cerealis and Sclerotinia sclerotiorum. Among them, compound 9c-7 exhibited the highest antifungal activities against R. solani, R. cerealis and S. sclerotiorum in vitro with IC50 values of 0.013, 1.608 and 1.874?μg/mL, respectively. Notably, compound 9c-7 still presented the highest fungicidal activities against R. solani in vivo with an IC50 value of 22.21?μg/mL. Molecular docking simulation results reveal that compound 9c-7 binds well to the hydrophobic pockets of the receptor protein succinate dehydrogenase. This study suggests that compound 9c-7 could act as a potential fungicide to be used for further optimization.

Compound with heterocyclic ligand and preparation method and application thereof

The invention provides a compound with a heterocyclic ligand and a preparation method and application thereof. According to the compound with the heterocyclic ligand, the specific heterocyclic ligand is selected to be combined with metal aluminum, so that after the obtained organic compound is applied to an organic light-emitting device, the light-emitting efficiency of the device is improved, and the service life is long.