103323-43-9

Basic information

• Product Name: 8-(3-HYDROXYPROPYL)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE
• Synonyms: 8-(3-HYDROXYPROPYL)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE
• CAS NO: 103323-43-9
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.25
• Mol File: 103323-43-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-(3-HYDROXYPROPYL)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(3-HYDROXYPROPYL)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE(103323-43-9)
• EPA Substance Registry System: 8-(3-HYDROXYPROPYL)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE(103323-43-9)

Safety Data

• Hazardous Substances Data: 103323-43-9(Hazardous Substances Data)

Upstream product

• 542-05-2 acetonedicarboxylic acid 
• 638-37-9 butanedial 
• 156-87-6 propan-1-ol-3-amine 

Downstream Products

• 174486-39-6 N-(endo-8-(3-hydroxy)propyl-8-azabicyclo[3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxamide 
• 118413-59-5 N-<γ-(4-bromobenzoyloxy)propyl>northropine 
• 118413-58-4 N-<γ-(4-chlorobenzoyloxy)propyl>northropine 
• 124608-79-3 N-<γ-(α,α-diphenylpropionyloxy)propyl>nortropinone 
• 124608-78-2 N-<γ-(diphenylacetyloxy)propyl>nortropinone 

Relevant articles and documents

A practical procedure for preparation of N-(endo-8-(3-hydroxy)propyl-8-azabicyclo [3.2.1]oct-3-yl)-1-isopropyl-2-oxo-1,2-dihydro-3-quinoline-carboxamide (TS-951)

Effective and convergent process for the preparation of a potent and selective 5-HT4 receptor agonist, the title compound, by reaction of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid (6) with endo-3-amino-8-(3-hydroxypropyl)-8-azabicyclo[3.2.1]octane dihydrochloride (20) has been described. Furthermore, this process was developed to pilot plant scale. 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid (6) was prepared from 2-aminobenzyl alcohol (12) in 65.6% overall yield and endo-3-amino-8-(3-hydroxypropyl)-8-azabicyclo[3.2.1]octane dihydrochloride (20) was prepared from 2,5-dimethoxyfuran (16) in 43.4% overall yield.

Quinolinecarboxylic acid derivatives

Quinolinecarboxylic acid derivatives represented by the following formula: STR1 wherein C is hydroxymethyl, methoxy, ethoxy or morpholinyl, or pharmaceutically acceptable salts thereof exhibit a potent action for stimulating a serotonin 4 receptor. The compounds exhibit an action of enhancing the gastrointestinal motor function to improve the gastrointestinal conditions such as heartburn, anorexia, bowel pain, abdominal distension, etc., accompanied by chronic gastritis, diabetes mellitus or postoperative gastroparesis, and are thus effective for the treatment of gastro-esophagal reflux, intestinal pseudo-obstruction and constipation.