103324-37-4Relevant articles and documents
Novel phenyl-substituted imidazolidines, process for preparation thereof, medicaments comprising said compounds and use thereof
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Page/Page column 50, (2011/08/04)
The invention relates to compounds of formula (I) wherein the groups have stated meanings, and to their physiologically compatible salts. Said compounds are suitable, for example, as anti-obesity drugs and for treating cardiometabolic syndrome.
5-Benzylidene-1,2-dihydrochromeno[3,4-f]quinolines as selective progesterone receptor modulators
Zhi, Lin,Tegley, Christopher M.,Pio, Barbara,Edwards, James P.,Motamedi, Mehrnouch,Jones, Todd K.,Marschke, Keith B.,Mais, Dale E.,Risek, Boris,Schrader, William T.
, p. 4104 - 4112 (2007/10/03)
A series of 5-benylidene-1,2-dihydrochromeno[3,4-f]quinolines (4) were synthesized and tested in bioassays to evaluate their progestational activities, receptor- and tissue-selectivity profiles as selective progesterone receptor modulators (SPRMs). Most of the new analogues exhibited as highly potent progestins with more than 100-fold receptor selectivity over other steroid hormone receptors and LG120920 (7b) demonstrated tissue selectivity toward uterus and vagina versus breasts in a rodent model after oral administration.