1033244-93-7Relevant articles and documents
Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: Exploration of effective compounds in arthritis models
Shimizu, Hiroki,Yamasaki, Tomonori,Yoneda, Yoshiyuki,Muro, Fumihito,Hamada, Tomoaki,Yasukochi, Takanori,Tanaka, Shinji,Toki, Tadashi,Yokoyama, Mika,Morishita, Kaoru,Iimura, Shin
scheme or table, p. 4550 - 4555 (2011/09/12)
We have discovered imidazo[1,2-b]pyridazine derivatives that show suppressive activity of inflammation in arthritis models. We optimized the substructures of imidazo[1,2-b]pyridazine derivatives to combine potent IKKβ inhibitory activity, TNFα inhibitory
