1033301-29-9Relevant articles and documents
Chemical modification of plant alkaloids. 5. Spirocyclic systems based on cotarnine and barbituric acids
Krasnov,Kartsev,Khrustalev
, p. 48 - 54 (2008)
Cotarnine was reacted with barbituric acid and its N-alkylbartituric and 1,3-dimethyl-2-thio analogs under forcing conditions to produce spirocyclic systems. Adducts, further transformations of which included skeletal rearrangements (a type of T-reaction) and subsequent deamination, were formed in the first step. The reaction of N-methylcotarnine and 1,3-dimethylbarbituric acid was analogous. The properties of the spirocyclic products were studied. They were further modified at the CH-acid and aromatic moieties.