103344-68-9Relevant academic research and scientific papers
Divergent synthesis of (quinoxalin-2-yl)-1,3-oxazines and pyrimido[1,6-a]quinoxalines via the cycloaddition reaction of acyl(quinoxalinyl)ketenes
Kasatkina, Svetlana,Stepanova, Ekaterina,Dmitriev, Maksim,Mokrushin, Ivan,Maslivets, Andrey
, (2019)
A facile synthetic approach towards two distinct quinoxaline-based heterocyclic scaffolds has been developed from the cycloaddition of acyl(quinoxalinyl)ketenes with carbodiimides. The described reaction represents the first example of a divergent synthesis based on acyl(quinoxalinyl)ketenes providing (quinoxalin-2-yl)-1,3-oxazines or pyrimido[1,6-a]quinoxalines depending on the type of the acyl substituent in the ketenes. The key reactants, acyl(quinoxalinyl)ketenes, are generated in situ via the thermal decarbonylation of readily available pyrroloquinoxaline oxo-derivatives. The proposed diversity-oriented synthesis provides facile access to a library of skeletally diverse pharmaceutically interesting quinoxaline-based heterocycles from inexpensive reagents.
CHEMISTRY OF OXALYL DERIVATIVES OF METHYL KETONES. XLII. RING OPENING IN 5-ARYL-2,3-DIHYDRO-2,3-FURANDIONES BY THE ACTION OF AROMATIC AMINES IN TOLUENE. EFFECT OF SUBSTITUENTS IN THE NUCLEOPHILIC REAGENTS AND SUBSTRATE ON THE RATE OF THE NONCATALYTIC REAC
Kozlov, A. P.,Sychev, D. I.,Andreichikov, Yu. S.
, p. 1965 - 1972 (2007/10/02)
The kinetics of the reactions of 5-aryl-2,3-dihydro-2,3-furandiones with aromatic amines were investigated by a spectrophotometric method.On the basis of an analysis of the dependence of the reaction rate on the nature of the substituents in the substrate
