10335-61-2Relevant academic research and scientific papers
Electrochemical synthesis of 1,2,4-triazole-fused heterocycles
Ye, Zenghui,Ding, Mingruo,Wu, Yanqi,Li, Yong,Hua, Wenkai,Zhang, Fengzhi
, p. 1732 - 1737 (2018)
A reagent-free intramolecular dehydrogenative C-N cross-coupling reaction has been developed under mild electrolytic conditions. In this atom- and step-economical one-pot process, valuable 1,2,4-triazolo[4,3-a]pyridines and related heterocyclic compounds could be synthesized efficiently from commercially available aliphatic or (hetero)aromatic aldehydes and 2-hydrazinopyridines. Various functional groups are compatible with this metal- and oxidant-free protocol which can be carried out on a gram scale easily. This novel method was applied to the synthesis of one of the top-selling drugs Xanax and late stage functionalization for generating chemical diversity in biologically relevant lead molecules.
Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization
Li, Ertong,Hu, Zhiyuan,Song, Lina,Yu, Wenquan,Chang, Junbiao
, p. 11022 - 11027 (2016/07/27)
A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio
Synthesis and antimicrobial effects of 1,3,5-substituted phenyl formazans
Uraz, Guven,Yilmaz, Ebru,Tezcan, Habibe,Porsuk, Nesrin,Imamoglu, Gamze,Kartli, Onur Savas
experimental part, p. 1924 - 1926 (2012/09/07)
In this study, novel formazans with various substituents on 1,3,5-phenyl rings were synthesized and their structures were elucidated with the use of elemental analysis, mass,1H NMR,13C NMR, IR, UV-VIS spectra. Also, antimicrobial effects of formazans were tested against selected microorganism, Staphylococus aureus, S. epidermidis, S. saprophyticus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae. Moreover, the antiyeast effects of the formazans are seen on the Candida kefir, C. glabrata, C. tropicalis, Cryptococcus neofarmans, Saccharomyces cerevisiae. In the present study, it was generally observed that the formazans were very active against Candida kefir, C. tropicalis, Cryptococcus neofarmans and Saccharomyces cerevisiae.
