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103360-04-9

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103360-04-9 Usage

Chemical Properties

White to yellow to brown solid

Uses

(4-Fluorophenyl)methanesulfonyl chloride

Check Digit Verification of cas no

The CAS Registry Mumber 103360-04-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,3,6 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 103360-04:
(8*1)+(7*0)+(6*3)+(5*3)+(4*6)+(3*0)+(2*0)+(1*4)=69
69 % 10 = 9
So 103360-04-9 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClFO2S/c8-12(10,11)5-6-1-3-7(9)4-2-6/h1-4H,5H2

103360-04-9 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (H31605)  4-Fluoro-alpha-toluenesulfonyl chloride, 97%   

  • 103360-04-9

  • 250mg

  • 924.0CNY

  • Detail
  • Alfa Aesar

  • (H31605)  4-Fluoro-alpha-toluenesulfonyl chloride, 97%   

  • 103360-04-9

  • 1g

  • 1520.0CNY

  • Detail
  • Aldrich

  • (700894)  4-Fluorobenzylsulfonylchloride  97%

  • 103360-04-9

  • 700894-1G

  • 1,552.59CNY

  • Detail

103360-04-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Fluorobenzylsulfonyl chloride

1.2 Other means of identification

Product number -
Other names (4-Fluorophenyl)methanesulfonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103360-04-9 SDS

103360-04-9Relevant articles and documents

Alkyne Linchpin Strategy for Drug:Pharmacophore Conjugation: Experimental and Computational Realization of a Meta-Selective Inverse Sonogashira Coupling

Bhowmick, Suman,Guin, Srimanta,Kumar Singh, Vikas,Maiti, Debabrata,Paton, Robert S.,Porey, Sandip,Zhang, Xinglong

, p. 3762 - 3774 (2020)

The late-stage functionalization (LSF) of pharmaceutical and agrochemical compounds by the site-selective activation of C-H bonds provides access to diverse structural analogs and expands synthetically-accessible chemical space. We report a C-H functionalization LSF strategy that hinges on the use of an alkyne linchpin to assemble conjugates of sp2-rich marketed pharmaceuticals and agrochemicals with sp3-rich 3D fragments and natural products. This is accomplished through a template-assisted inverse Sonogashira reaction that displays high levels of selectivity for the meta position. This protocol is also amenable to distal structural modifications of α-amino acids. The transformation of alkyne functionality to other functional groups further highlights the applicative potential. Computational and experimental mechanistic studies shed light on the detailed mechanism. Turnover-limiting 1,2-migratory insertion of the bromoalkyne coupling partner occurs after relatively fast C-H activation. While this insertion occurs unselectively, regioconvergence results from one of the adducts undergoing a 1,2-trialkylsilyl migration to form the alkynylated product. A heterobimetallic Pd-Ag transition structure is essential for product formation in the β-bromide elimination step.

Rhodium-Catalyzed meta-C?H Functionalization of Arenes

Bera, Milan,Agasti, Soumitra,Chowdhury, Rajdip,Mondal, Rahul,Pal, Debasis,Maiti, Debabrata

, p. 5272 - 5276 (2017)

Rhodium-catalyzed ortho-C?H functionalization is well known in the literature. Described herein is the Xphos-supported rhodium catalysis of meta-C?H olefination of benzylsulfonic acid and phenyl acetic acid frameworks with the assistance of a para-methoxy-substituted cyano phenol as the directing group. Complete mono-selectivity is observed for both scaffolds. A wide range of olefins and functional groups attached to arene are tolerated in this protocol.

Simple preparation method of p-hydrazinobenzenesulfonic acid compound

-

Paragraph 0020; 0022; 0025; 0029; 0031; 0034, (2020/04/29)

The invention provides a preparation method of a p-hydrazinobenzenesulfonic acid compound. P-fluorobenzyl chloride is used as an initial raw material, and a target product is obtained through sulfonation, acylating chlorination, condensation, substitution and other methods. The raw materials are easy to obtain, the operation is easy and convenient, the cost is low, the risk is low, and the compound has a wide application prospect in the field of medicinal chemistry.

Optimization of P2Y12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

Kong, Deyu,Xue, Tao,Guo, Bin,Cheng, Jianjun,Liu, Shunyin,Wei, Jianhai,Lu, Zhengyu,Liu, Haoran,Gong, Guoqing,Lan, Tian,Hu, Wenhao,Yang, Yushe

supporting information, p. 3088 - 3106 (2019/04/01)

P2Y12 antagonists are widely used as antiplatelet agents for the prevention and treatment of arterial thrombosis. Based on the scaffold of a known P2Y12 antagonist AZD1283, a series of novel bicyclic pyridine derivatives were designed and synthesized. The cyclization of the ester substituent on the pyridine ring to the ortho-methyl group led to lactone analogues of AZD1283 that showed significantly enhanced metabolic stability in subsequent structure-pharmacokinetic relationship studies. The metabolic stability was further enhanced by adding a 4-methyl substituent to the piperidinyl moiety. Compound 58l displayed potent inhibition of platelet aggregation in vitro as well as antithrombotic efficacy in a rat ferric chloride model. Moreover, 58l showed a safety profile that was superior to what was observed for clopidogrel in a rat tail-bleeding model. These results support the further evaluation of compound 58l as a promising drug candidate.

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