1033618-49-3Relevant academic research and scientific papers
Development of Chiral C2-Symmetric N-Heterocyclic Carbene Rh(I) Catalysts through Control of Their Steric Properties
Abadie, Marc-Antoine,Macintyre, Kirsty,Boulho, Cédric,Hoggan, Peter,Capet, Frédéric,Agbossou-Niedercorn, Francine,Michon, Christophe
, p. 536 - 543 (2019/01/14)
Chiral square-planar Rh(I) complexes based on new C2-symmetric NHC ligands have been synthesized selectively in a few steps as single diastereoisomers. These chiral precatalysts were applied to the asymmetric transfer hydrogenation of 1-phenylp
C2 symmetric chiral NHC ligand for asymmetric quaternary carbon constructing copper-catalyzed conjugate addition of Grignard reagents to 3-substituted cyclohexenones
Matsumoto, Yasumasa,Yamada, Ken-Ichi,Tomioka, Kiyoshi
, p. 4578 - 4581 (2008/09/21)
(Chemical Equation Presented) The asymmetric construction of quaternary carbon centers by conjugate addition of Grignard reagents to 3-methyl- and 3-ethylcyclohexenones was realized in a maximum enantioselectivity of 80% by using a C2 symmetric chiral N-heterocyclic carbene (NHC)-copper catalyst, generated from (4S,5S)-1,3-bis(2-methoxyphenyl)-4,5-diphenyl-4,5- dihydro-1H-imidazol-3-ium tetrafluoroborate and copper(II) triflate. The stereostructures of the NHC-Au complexes were analyzed by X-ray crystallography, which rationalized the good stereocontrolling ability of N-aryl NHCs.
