1033620-20-0Relevant articles and documents
Screening of a phosphite-phosphoramidite ligand library for palladium-catalysed asymmetric allylic substitution reactions: The origin of enantioselectivity
Pamies, Oscar,Dieguez, Montserrat
, p. 944 - 960 (2008)
We have designed a new library of readily available, highly modular phosphite-phosphoramidite ligands for asymmetric allylic substitution reactions. They are easily prepared in one step from commercially available chiral 1,2-amino alcohols. The introduction of a phosphoramidite moiety into the ligand design is highly advantageous for the product outcome. This ligand library affords high reaction rates (TOFs of up to 800 mol (mol h)-1) and enantioselectivities (ees of up to 99%) and, at the same time, contains a broad range of disubstituted hindered and unhindered substrate types. NMR study of the Pd-π-allyl intermediates provide a deeper understanding of the effect of the ligand parameters on the origin of cnantioselectivity.