1033735-94-2 Usage
Uses
Used in Pharmaceutical Research:
GNE-493 is used as an experimental compound for its potential anticancer activities. It is particularly valuable in the development of targeted therapies against various types of cancer due to its ability to inhibit the PI3K/mTOR pathway, a common mechanism in many cancer cells that promotes their growth and survival.
Used in Cancer Treatment:
GNE-493 is used as a therapeutic agent for the treatment of cancer. Its dual inhibition of the PI3K and mTOR pathways makes it a promising candidate for treating cancers that are dependent on these pathways for their growth and proliferation, potentially offering a new approach to managing cancer in patients.
Used in Drug Development:
In the drug development industry, GNE-493 is used as a lead compound for the creation of new drugs. Its unique mechanism of action provides a foundation for the development of novel cancer therapies that could be more effective and have fewer side effects compared to existing treatments.
Used in Scientific Research:
GNE-493 is used as a research tool in laboratories to study the role of the PI3K/mTOR pathway in various biological processes and diseases, including cancer. It helps researchers understand the molecular mechanisms underlying the development and progression of cancer, which can lead to the discovery of new therapeutic targets and strategies.
Used in Clinical Trials:
GNE-493 is used in clinical trials to evaluate its safety, efficacy, and optimal dosing regimens for the treatment of specific types of cancer. These trials are crucial for determining whether GNE-493 can be successfully translated from the laboratory to the clinic as a new cancer treatment option.
Check Digit Verification of cas no
The CAS Registry Mumber 1033735-94-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,3,7,3 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1033735-94:
(9*1)+(8*0)+(7*3)+(6*3)+(5*7)+(4*3)+(3*5)+(2*9)+(1*4)=132
132 % 10 = 2
So 1033735-94-2 is a valid CAS Registry Number.
InChI:InChI=1S/C17H20N6O2S/c1-17(2,24)12-7-11-13(26-12)15(23-3-5-25-6-4-23)22-14(21-11)10-8-19-16(18)20-9-10/h7-9,24H,3-6H2,1-2H3,(H2,18,19,20)
1033735-94-2Relevant academic research and scientific papers
Discovery of (thienopyrimidin-2-yl)aminopyrimidines as potent, selective, and orally available Pan-PI3-kinase and dual Pan-PI3-kinase/mTOR inhibitors for the treatment of cancer
Sutherlin, Daniel P.,Sampath, Deepak,Berry, Megan,Castanedo, Georgette,Chang, Zhigang,Chuckowree, Irina,Dotson, Jenna,Folkes, Adrian,Friedman, Lori,Goldsmith, Richard,Heffron, Tim,Lee, Leslie,Lesnick, John,Lewis, Cristina,Mathieu, Simon,Nonomiya, Jim,Olivero, Alan,Pang, Jodie,Prior, Wei Wei,Salphati, Laurent,Sideris, Steve,Tian, Qingping,Tsui, Vickie,Wan, Nan Chi,Wang, Shumei,Wiesmann, Christian,Wong, Susan,Zhu, Bing-Yan
experimental part, p. 1086 - 1097 (2010/08/05)
The PI3K/AKT/mTOR pathway has been shown to play an important role in cancer. Starting with compounds 1 and 2 (GDC-0941) as templates, (thienopyrimidin-2-yl)aminopyrimidines were discovered as potent inhibitors of PI3K or both PI3K and mTOR. Structural in
PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE
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Page/Page column 203-204, (2008/12/06)
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed. Formula (Ic) and (Id).
