1033736-87-6

Upstream product

• 1187758-97-9 (1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl diethyl phosphate 
• 1033736-99-0 (4-oxo-3-phenyl-4H-1,1-dioxothiochromen-2-yl)methyl dodecanoate 
• 1033736-90-1 C₃₈H₃₀O₁₀S₂ 
• 1033736-93-4 4-hydroxybutyl (4-oxo-3-phenyl-4H-thiochromen-2-yl)methylcarbonate 
• 1033736-80-9 C₃₃H₂₇NO₇S 
• 112-16-3 n-dodecanoyl chloride 
• 1033736-38-7 2-(hydroxymethyl)-3-phenyl-4H-thiochromen-4-one 1,1-dioxide 

Relevant academic research and scientific papers

Study of the Paternò–Büchi type photolabile protecting group and application to various acids

An efficient photolabile protecting group, thiochromone S,S-dioxides with the diazomethyl group for phosphate derivatives, amino acids and sulfonic acids was developed. Protection and photodeprotection reactions proceeded smoothly under mild conditions without any catalyst.1H NMR and HPLC spectra studies demonstrated the photolysis properties of the photolabile protecting group and gave an exact quantification of the released substrates. Specially, the photoproduct derived from the thiochromone derivatives following Paternò–Büchi type photo-cycloaddition showed high fluorescence intensity. This fluorescent characteristic demonstrated the photodeprotection progress also can be monitored by fluorescence spectra.

PHOTODISSOCIABLE PROTECTIVE GROUP

The present invention provides a photolabile protecting group that can be removed by light irradiation under mild conditions. More specifically, the present invention provides a method comprising protecting a reactive functional group (e.g., a hydroxyl group, amino group, carboxyl group, carbonyl group, phosphodiester group, etc.) by the photolabile protecting group, and then removing the photolabile protecting group simply by light irradiation under neutral conditions. The present invention relates to a compound represented by Formula (3): wherein Ar1 is an optionally substituted aromatic or heteroaromatic ring, Ar2 is an optionally substituted aryl or heteroaryl group, X is a leaving group, and n is an integer of 1 or 2; and a method of protecting and deprotecting an amino group etc. using the compound.