1033749-65-3Relevant academic research and scientific papers
1-Allyl- and 1-benzyl-3-methyl-1,2,3-triazolium salts via tandem click transformations
Fletcher, James T.,Keeney, Matthew E.,Walz, Sara E.
experimental part, p. 3339 - 3345 (2010/11/17)
A series of 1-allylated and 1-benzylated 1,2,3-triazoles with varying substituents at the 4-position were prepared in yields ranging from 74-98% using a two-step one-pot click transformation. This tandem reaction involved the nucleophilic substitution of allyl chloride and benzyl bromide with sodium azide to form organic azide intermediates followed by Cu-catalyzed Huisgen 1,3-dipolar cycloaddition with alkyne reactants in a single reaction pot without the need for sequentially separating reaction steps. 1-Allyl- and 1-benzyl-4-alkyl-1,2,3-triazoles possessing linear alkyl chains underwent efficient N-alkylation at the 3-position with methyl iodide, while tert-butyl and phenyl derivatives did not. Each of the 1-allyl- and 1-benzyl-3-methyl-4- alkyl-1,2,3-triazolium iodide salts prepared was a viscous liquid at room temperature with a stable shelf life.
A novel and versatile access to task-specific ionic liquids based on 1,2,3-triazolium salts
Hanelt, Sven,Liebscher, Jürgen
experimental part, p. 1058 - 1060 (2009/04/04)
Novel task-specific ionic liquids based on 1,2,3-triazolium salts were prepared in a straightforward two-step procedure. Azides and alkynes were transformed into 1,4-disubstituted 1,2,3-triazoles by Cu-catalyzed click reaction. Subsequent alkylation affor
