1033749-83-5

Upstream product

• 858104-50-4 (4-{(2R,3R)-1-(4-fluoro-phenyl)-3-[(RS)-2-(4-fluoro-phenyl)-2-oxoethylsulfanyl]-4-oxo-azetidin-2-yl}-phenoxy)-acetic acid 
• 13518-40-6 t-butyl D-valinate hydrochloride 
• 917753-28-7 {4-[(2R,3R)-3-{[2-(4-chlorophenyl)-2-oxoethyl]thio}-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenoxy}acetic acid 
• 858104-44-6 tert-butyl (4-{[(4-fluorophenyl)imino]methyl}phenoxy)acetate 
• 858104-47-9 (3R,4R)-1-(4-fluorophenyl)-3-(4-methoxybenzylsulphanyl)-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one 
• 123-08-0 4-hydroxy-benzaldehyde 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 917753-29-8 C₂₉H₂₇ClFNO₅S 
• 276884-77-6 tert-Butyl (4-formylphenoxy)acetate 
• 858104-46-8 tert-butyl (4-{(1R)-1-[(4-fluorophenyl)amino]-2-[(4-methoxybenzyl)thio]-3-oxo-3-[(4S)-2-oxo-4-phenyl-1,3-oxazolidin-3-yl]propyl}phenoxy)acetate 
• 858104-49-1 (3R,4R)-1-(4-fluorophenyl)-3-[(4-fluorobenzoyl)methylthio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one 
• 858104-48-0 (3R,4R)-1-(4-fluorophenyl)-3-[(3-nitropyridin-2-yl)dithio]-4-[4-(t-butoxycarbonylmethoxy)phenyl]azetidin-2-one 

Downstream Products

• 858104-78-6 C₄₅H₅₆F₂N₄O₉S 
• 858104-77-5 C₄₃H₄₅F₂N₃O₈S 
• 858104-70-8 C₄₁H₄₉F₂N₃O₈S 
• 1033695-21-4 C₄₁H₄₉F₂N₃O₈S 
• 858104-72-0 C₃₉H₄₅F₂N₃O₇S 
• 858104-73-1 C₃₉H₄₅F₂N₃O₇S 
• 1033696-28-4 C₃₃H₃₃F₂N₃O₈S 
• 858104-71-9 C₃₆H₃₉F₂N₃O₇S 

Relevant academic research and scientific papers

NOVEL 2-AZETIDINONE DERIVATIVES AS CHOLESTEROL ABSORPTION INHIBITORS USEFUL FOR THE TREATMENT OF HYPERLIPIDAEMIC CONDITIONS

The application relates to novel 2-azetidinone derivatives of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof . The compounds are cholesterol absorption inhibitors and are useful in the treatment of hyperlipidaemic conditions, including atherosclerosis, Alzheimers' disease and cholesterol associated tumours. The application also relates to pharmaceutical formulations comprising such compounds and to processes for their preparation.

DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY

Compounds of formula (I) (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia are described. Processes for their manufacture and pharmaceutical compositions containing them are also described.