1033772-52-9Relevant academic research and scientific papers
Nickel complexes of a pincer NN2 ligand: Multiple carbon-chloride activation of CH2Cl2 and CHCl3 leads to selective carbon-carbon bond formation
Csok, Zsolt,Vechorkin, Oleg,Harkins, Seth B.,Scopelliti, Rosario,Hu, Xile
, p. 8156 - 8157 (2008)
A new pincer-type bis(amino)amine (NN2) ligand and its lithium and nickel complexes, including Ni(II) methyl, ethyl, and phenyl complexes, were synthesized. The Ni(II) alkyl complexes react cleanly with alkyl halides including chlorides to form C-C coupled products and Ni(II) halides. More interestingly, the Ni(II) alkyls undergo unprecedented reactions with CH2Cl2 and CHCl3 to cleave all the C-Cl bonds and replace them with C-C bonds. The reactions are highly selective and lead to the first efficient catalytic coupling of CH2Cl2 with alkyl Grignards. A conversion of 82% and a turnover number of 47 are achieved within minutes. Coupling of CD2Cl2 and 1,1-dichloro-3,3-dimethylbutane with nBuMgCl is also realized. Preliminary mechanistic study suggests a radical initiated process for these reactions. Copyright
