1033780-93-6Relevant academic research and scientific papers
A small synthetic molecule functions as a chloride-bicarbonate dual-transporter and induces chloride secretion in cells
Liu, Peng-Yun,Li, Shing-To,Shen, Fang-Fang,Ko, Wing-Hung,Yao, Xiao-Qiang,Yang, Dan
, p. 7380 - 7383 (2016)
A C2 symmetric small molecule composed of l-phenylalanine and isophthalamide was found to function as a Cl-/HCO3- dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.
Synthetic Ion Channels
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Page/Page column 17, (2008/12/06)
Provided herein are self-assembling compounds that can form ion channels in lipid bilayers or cell membranes and ion-channel-forming compositions comprising the self-assembling compounds. Also provided are methods of making and using the ion channels formed from a plurality of molecules of the self-assembling compounds. Further, provided are methods of treating or preventing conditions and diseases that are related to the dysfunction of ion channels, including chloride channels.
