1033834-86-4Relevant academic research and scientific papers
5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase
Tarver, James E.,Jessop, Theodore C.,Carlsen, Marianne,Augeri, David J.,Fu, Qinghong,Healy, Jason P.,Heim-Riether, Alexander,Xu, Amy,Taylor, Jerry A.,Shen, Min,Keyes, Philip E.,David Kimball,Yu, Xuan-Chuan,Miranda, Maricar,Liu, Qingyun,Swaffield, Jonathan C.,Nouraldeen, Amr,Wilson, Alan G.E.,Finch, Rick,Jhaver, Kanchan,Foushee, Ann Marie DiGeorge,Anderson, Steve,Oravecz, Tamas,Carson, Kenneth G.
scheme or table, p. 6780 - 6783 (2010/06/14)
A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good combination of cellular potency and pharmacokinetic parameters
O-LINKED PYRIMIDIN-4-AMINE-BASED COMPOUNDS, COMPOSITIONS COMPRISING THEM, AND METHODS OF THEIR USE TO TREAT CANCER
-
Page/Page column 28, (2008/12/06)
O-linked pyrimidin-4-amine-based compounds, pharmaceutical compositions comprising them, and methods of their use are described. Particular compounds of the invention are of formula I:
