1033853-05-2Relevant academic research and scientific papers
Copper-catalyzed decarboxylative C-P cross-coupling of alkynyl acids with H-phosphine oxides: A facile and selective synthesis of (E)-1-alkenylphosphine oxides
Hu, Gaobo,Gao, Yuxing,Zhao, Yufen
, p. 4464 - 4467 (2014)
A novel and efficient copper-catalyzed decarboxylative cross-coupling of alkynyl acids for the stereoselective synthesis of E-alkenylphosphine oxides has been developed. In the presence of 10 mol % of CuCl without added ligand, base, and additive, various alkynyl acids reacted with H-phosphine oxides to afford E-alkenylphosphine oxides with operational simplicity, broad substrate scope, and the stereoselectivity for E-isomers.
Rhodium-catalyzed reaction of 1-alkynylphosphines with water yielding (E')-l-alkenylphosphine oxides
Kondoh, Azusa,Yorimitsu, Hideki,Oshima, Koichiro
experimental part, p. 502 - 505 (2009/04/07)
Treatment of 1-alkynylphosphines with a rhodium catalyst in l,4-dioxane/H20 at reflux provides (E)-1 -alkenyl-phosphine oxides in good yields with perfect stereoselectivity. The reaction proceeds as follows. Oxidative addition of 1 -alkynylphosphine to rhodium followed by hydrolysis yields the corresponding terminal alkyne and diphenylphos-phine oxide. Rhodium-catalyzed hydrophosphinylation of the terminal alkyne then proceeds to afford (E)-1 -alkenylphosphine oxide.
