1033883-53-2Relevant academic research and scientific papers
Total synthesis of cis-sylvaticin
Brown, Lynda J.,Spurr, Ian B.,Kemp, Stephen C.,Camp, Nicholas P.,Gibson, Karl R.,Brown, Richard C. D.
supporting information; experimental part, p. 2489 - 2492 (2009/05/27)
(Chemical Equation Presented) An asymmetric total synthesis of (+)-cis-sylvaticin is described. Key steps include the use of permanganate-mediated oxidative cyclization of 1,5-dienes to synthesize the two major fragments 2 and 3 and a catalytically efficient tethered RCM to unite these THF-containing fragments. In addition, t-BuP4 base was found to reliably promote rapid alkylation of the butenolide precursor fragment 4.
