1034014-41-9

Upstream product

• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 101527-40-6 5'-O-tert-butyldiphenylsilylthymidine 
• 50-89-5 thymidine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 
• 854389-39-2 [(2R,3S,5R)-3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxymethyl]-phosphonic acid monomethyl ester 

Relevant academic research and scientific papers

Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides

An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.