1034046-89-3

Upstream product

• 1039715-36-0 C₁₃H₇ClF₃N₃O 
• 1034047-10-3 7-chloro-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine 
• 1034047-04-5 6-[(4-tert-butylphenyl)sulfonyl]-7-chloro-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine 
• 1354785-39-9 7-cyano-6-{[4-(tert-butyl)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine 
• 21745-41-5 2,3-diaminochlorobenzene 
• 59483-54-4 3-chloro-2-nitro-aniline 

Downstream Products

• 1039715-74-6 C₃₃H₃₀F₃N₅O₄S 
• 1034044-54-6 {3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol 
• 1034044-54-6 {3-[6-[(4-tert-butylphenyl)sulfonyl]-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b]-[1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}methanol 

Relevant academic research and scientific papers

Discovery of MK-7725, a potent, selective bombesin receptor subtype-3 agonist for the treatment of obesity

Extensive structure-activity relationship studies of a series derived from atropisomer 1, a previously described chiral benzodiazepine sulfonamide series, led to a potent, brain penetrant and selective compound with excellent preclinical pharmacokinetic a

SUBSTITUTED DIAZEPINE SULFONAMIDES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS

Certain novel substituted diazepine sulfonamides are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.