103411-59-2Relevant academic research and scientific papers
Studies on the biosynthesis of the mycotoxin austin, a meroterpenoid metabolite of Aspergillus ustus
Ahmed,Scott,Stenzel,Simpson,Moore,Trimble,Arai,Vederas
, p. 807 - 816 (2007/10/02)
Incorporations of 13C-labelled acetates and methionine into the mycotoxin austin in cultures of Aspergillus ustus give a labelling pattern consistent with a mixed polyketide-terpenoid pathway. Incorporations of 14C and 2H labelled 3,5-dimethylorsellinate confirm the intermediacy of a preformed tetraketide-derived phenolic precursor. Further information on the mechanisms involved in the modifications of both the farnesyl- and tetraketide-derived portions of the molecule are provided by incorporation studies with [1-13C,18O2]acetate, [methyl-13C,2H3]methionine, 13C,18O-labelled dimethylorsellinate, 18O2 gas and [6-13C,6-2H3]mevalonic acid lactone.
