1034141-47-3Relevant academic research and scientific papers
Efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide enabling stepwise double functionalisation to afford CF3-substituted tertiary alcohols
Keeling, Steven P.,Campbell, Ian B.,Coe, Diane M.,Cooper, Tony W.J.,Hardy, George W.,Jack, Torquil I.,Jones, Haydn T.,Needham, Deborah,Shipley, Tracy J.,Skone, Philip A.,Sutton, Peter W.,Weingarten, Gordon A.,Macdonald, Simon J.F.
, p. 5101 - 5104 (2008/12/22)
The efficient synthesis of an α-trifluoromethyl-α-tosyloxymethyl epoxide is reported. This highly versatile building block may be reacted sequentially with two different nucleophiles to furnish α-trifluoromethyl tertiary alcohols. Furthermore, the two enantiomers of this key intermediate have been separated using chiral HPLC and the stereochemistry shown to be conserved during subsequent chemical manipulations. Finally, an enzyme-driven desymmetrisation approach has been successfully employed to confer chirality on an intermediate in the sequence.
PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORTICOID RECEPTOR LIGANDS
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Page/Page column 61, (2008/12/06)
The present invention provides compounds of formula (I), a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.
