103420-29-7Relevant academic research and scientific papers
Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors
Doherty, Annette M.,Sircar, Ila,Kornberg, Brian E.,Quin, John,Winters, Thomas R.,et al.
, p. 2 - 14 (2007/10/02)
A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1 - P1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m
Synthesis of 6(S)-Amino-7-cyclohexyl-4,4-difluoro-3(R),5(R)-dihydroxy-2-methylheptane, a Novel Dipeptide Mimic
Sham, Hing L.,Rempel, Cheryl A.,Stein, Herman,Cohen, Jerome
, p. 904 - 905 (2007/10/02)
The incorporation of the novel dipeptide mimic (1), synthesized via Boc-L-cyclohexylalaninol (Boc = t-butoxycarbonyl), into a dipeptide sequence has led to a very potent renin inhibitor.
