103429-31-8 Usage
Uses
Different sources of media describe the Uses of 103429-31-8 differently. You can refer to the following data:
1. CTOP is a μ-opioid receptor antagonist which has been shown to regulate behaviour and expression in rats. An endogenous opioid peptide which may also be used in the treatment of pain through improved morphine tolerance via blocking of mTOR.
2. CTOP has been used:to study the anxiogenic effects induced by CTOP in mice and rat.to study the effect of μ-opioid antagonist, CTOP on the bovine milk-derived LF (BLF)-induced analgesia.to determine whether μ-opioid receptors act cooperatively with 5-hydroxytryptamine (5-HT1A) receptors to regulate the behaviors generated in the elevated T-maze (ETM).
General Description
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) is a selective cyclic μ-opioid receptor antagonist.
Biochem/physiol Actions
Selective ligand for μ-opioid receptors.
Check Digit Verification of cas no
The CAS Registry Mumber 103429-31-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,4,2 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 103429-31:
(8*1)+(7*0)+(6*3)+(5*4)+(4*2)+(3*9)+(2*3)+(1*1)=88
88 % 10 = 8
So 103429-31-8 is a valid CAS Registry Number.
InChI:InChI=1/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)
103429-31-8Relevant articles and documents
Design and Synthesis of Conformationally Constrained Somatostatin Analogues with High Potency and Specificity for μ Opioid Receptors
Pelton, John T.,Kazmierski, Wieslaw,Gulya, Karoly,Yamamura, Henry I.,Hruby, Victor J.
, p. 2370 - 2375 (2007/10/02)
A series of cyclic, conformationally constrained peptides related to somatostatin were designed and synthesized in an effort to develop highly selective and potent peptides for the μ opioid receptor.The following new peptides were prepared and tested for