1034299-55-2Relevant academic research and scientific papers
Synthesis of novel indole-based ring systems by acid-catalysed condensation from α-amino aldehydes and L-Trp-OMe
Gomez-Monterrey, Isabel M.,Campiglia, Pietro,Bertamino, Alessia,Aquino, Claudio,Mazzoni, Orazio,Diurno, Maria V.,Iacovino, Rosa,Saviano, Michele,Sala, Marina,Novellino, Ettore,Grieco, Paolo
experimental part, p. 1983 - 1992 (2009/04/03)
Acid-catalysed condensation of tryptophan with different α-amino aldehyde derivatives has been explored as a useful route to the synthesis of novel amino acid derived heterocycles and peptidomimetic scaffolds. By this approach, compounds containing a tetrahydro-β-carboline and a novel octahydropyrrolo[ 3′,2′:3,4]pyrrolo[2,3-b]indole system have been efficiently synthesized. Here we report the characterization of these new compounds and preliminary studies of the reactivity of the tetrahydro-β- carboline system. Wiley-VCH Verlag GmbH & Co. KGaA.
