103433-82-5

Upstream product

• 103433-81-4 6-[3-chloro-4-(ethoxycarbonylmethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone 

Downstream Products

• 850167-01-0 N-[2-({[4-(2,4-dimethoxyphenyl)(4H-benzo[b]pyrrolo[1,2-d]1,4-thiazinyl)]methyl}methylamino)ethyl]-2-[2-chloro-4-(6-oxo(1,4,5-trihydropyridazin-3-yl))phenoxy]acetamide 
• 850167-04-3 2-[2-chloro-4-(6-oxo(1,4,5-trihydropyridazin-3-yl))phenoxy]-N-(2-{[(1-oxo-4-phenyl(4H,3ah-benzo[e]pyrrolidino[2,1-c]1,4-thiazaperhydroin-7-yl))methyl]amino}ethyl)acetamide 
• 850167-05-4 2-[2-chloro-4-(6-oxo(1,4,5-trihydropyridazin-3-yl))phenoxy]-N-[2-({[4-(4-chlorophenyl)-4-hydroxy-1-oxobenzo[b]1,2,4-oxadiazolino[4,3-d]1,4-thiazaperhydroin-8-yl]methyl}amino)ethyl]acetamide 
• 103433-83-6 6-{3-chloro-4-[N-(2-morpholinoethyl)carbamoylmethoxy]phenyl}-4,5-dihydro-3(2H)-pyridazinone 
• 103415-66-3 6-[3-Chloro-4-(allylcarbamoylmethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone 
• 890042-55-4 2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-N-(4-hydroxybenzyl)-acetamide 
• 890042-56-5 2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-N-[2-(4-hydroxy-phenyl)-ethyl]-acetamide 
• 890042-53-2 N-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenoxy]acetylamino}ethyl)-2-(4-hydroxy-phenyl)-acetamide 

Relevant academic research and scientific papers

METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR AND A LINKER AND METHODS OF MAKING COMPOUNDS HAVING A BETA-ADRENERGIC INHIBITOR, A LINKER AND A PHOSPHODIESTERASE INHIBITOR

A method is provided for making compounds comprising a beta -adrenergic inhibiting moiety and a linking moiety, the method comprising: a) reacting a compound of formula (A): (R1 -(CH -O- CH2)) with at least one of NH3, NH

COMPOUNDS WITH PHOSPHODIESTERASE INHIBITING AND CALCIUM CHANNEL BLOCKING ACTIVITIES

The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.

DIHYDROPYRIDINE COMPOUNDS HAVING SIMULTANEOUS ABILITY TO BLOCK L-TYPE CALCIUM CHANNELS AND TO INHIBIT PHOSPHODIESTERASE TYPE 3 ACTIVITY

The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.

COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE

This invention provides compounds that possess inhibitory activity against β--adrenergic receptors and phosphodiesterase PDE, including phosphodiesterase 3 (PDE3 ). This invention further provides pharmaceutical compositions comprising such -compounds; methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine; and methods of preparing pharmaceutical compositions and compounds that possess inhibitory activity against ?-adrenergic receptors and PDE.