1034355-97-9

Upstream product

• 913376-49-5 benzyl 5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 106-89-8 epichlorohydrin 

Downstream Products

• 1361236-60-3 N-(3-fluoro-4-(7-methoxyquinolin-4-yloxy)phenyl)-5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide 
• 1361236-59-0 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 
• 1361236-58-9 benzyl 5-methyl-3-oxo-1-((2-oxooxazolidin-5-yl)methyl)-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 1361236-57-8 1-(3-((tert-butoxycarbonyl)amino)-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylic acid 
• 1361236-56-7 benzyl 1-(3-((tert-butoxycarbonyl)amino)-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 1361236-55-6 benzyl 1-(3-amino-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 1361236-54-5 benzyl 1-(3-azido-2-hydroxypropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

Selective β-hydroxyethylation at the N-1 position of a pyrazolone: Synthesis of benzyl 1-(β-hydroxyethyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro- 1H-pyrazole-4-carboxylate

Selective 2-hydroxyethylation at the N-1 position of benzyl 5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxylate with epoxides was achieved using either AlMe3 or Mg(ClO4)2 under mild conditions. The epoxide ring opening was both regioselective and stereospecific. Moderate to excellent yields were obtained from mono- and disubstituted epoxides with the exception of cis-dimethyl-2-butene oxide that gave only a trace amount of the product. Georg Thieme Verlag Stuttgart.