103438-88-6

Basic information

• Product Name: 2-FLUORO-3-METHOXYBENZALDEHYDE
• Synonyms: 2-FLUORO-3-METHOXYBENZALDEHYDE;2-Fluoro-3-methoxybenzaldehyde 96%;2-Fluoro-3-methoxybenzaldehyde96%;2-Fluoro-3-formylanisole
• CAS NO: 103438-88-6
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• Product Categories: Aldehydes;blocks;FluoroCompounds;Miscellaneous;Aldehyde;Aryl;Building Blocks;C8;Carbonyl Compounds;Aryl Fluorinated Building Blocks;C7-C8;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 103438-88-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 47-51 °C(lit.)
• Boiling Point: 239.909 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: White to yellow crystalline solid
• Density: 1.192 g/cm³
• Vapor Pressure: 0.0391mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Keep Cold
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-FLUORO-3-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-METHOXYBENZALDEHYDE(103438-88-6)
• EPA Substance Registry System: 2-FLUORO-3-METHOXYBENZALDEHYDE(103438-88-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-43
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 103438-88-6(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow crystalline solid

Uses

2-Fluoro-3-methoxybenzaldehyde is an intermediate in the synthesis of benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

InChI:InChI=1/C8H7FO2/c1-11-7-4-2-3-6(5-10)8(7)9/h2-5H,1H3

Upstream product

• 103438-87-5 2-amino-3-methoxybenzaldehyde dimethyl acetal 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 137654-20-7 2-fluoro-3-methoxybenzoic acid 
• 198203-94-0 2-fluoro-3-methoxybenzonitrile 
• 1000339-24-1 2-fluoro-3-hydroxybenzonitrile 
• 693220-47-2 2-fluoro-3,N-dimethoxy-N-methyl-benzamide 

Downstream Products

• 1213229-27-6 methyl (2-fluoro-3-(2,2-dibromoethenyl)phenyl) ether 
• 1204176-23-7 (R)-tert-butyl 1-(2-formyl-6-methoxyphenyl)piperidin-3-ylcarbamate 
• 1402353-80-3 1-ethynyl-2-fluoro-3-methoxybenzene 
• 1402353-84-7 ethyl (2R)-4-[5-(2-fluoro-3-methoxyphenyl)isoxazol-3-yl]-2-methyl-2-(methylsulfonyl)butanoate 
• 1353008-08-8 (2E,4E)-5-(2-fluoro-3-methoxyphenyl)-2-(4-fluorophenyl)penta-2,4-dienoic acid 
• 103438-90-0 3-benzyloxy-2-fluorobenzaldehyde 
• 295779-81-6 4-fluoro-5-methoxy-2,3-dihydro-1H-inden-1-one 
• 88791-07-5 7-methoxybenzothiophene-2-carboxylic acid 
• 88791-17-7 methyl 7-methoxybenzothiophene-2-carboxylate 

Relevant articles and documents

Synthesis method of elagolix intermediate

The invention relates to a synthesis method of an elagolix intermediate. Specifically, the invention provides a synthesis method of an elagolix intermediate compound X and an elagolix intermediate compound I. According to the method, 2-fluoro-3-methoxy-phenylacetic acid is used as a raw material, and the steps of cyclization, hydrolysis, amino protection, condensation, Mitsunobu reaction and the like are carried out in sequence, so that the elagolix intermediate compound X and the elagolix intermediate compound I are obtained. The method has the advantages of cheap and easily available reagents, high conversion rate, simple operation and low process cost, and is suitable for industrialization.

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferati

1-AMINO-2-OXY-SUBSTITUTED TETRAHYDRONAPHTALENE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS

The invention relates to polysubstituted tetrahydronaphtalene derivatives of formula (I), to methods for the production thereof, and to their use as antiphlogistics. The substituents are defined in Claim 1.