103440-59-1

Basic information

• Product Name: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-
• CAS NO: 103440-59-1
• Molecular Formula: C9H9IO3
• Molecular Weight: 292.073
• Mol File: 103440-59-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(103440-59-1)
• EPA Substance Registry System: Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)-(103440-59-1)

Safety Data

• Hazardous Substances Data: 103440-59-1(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(4-hydroxy-3-iodo-5-methoxyphenyl)- is a chemical compound with the molecular formula C9H9IO3. It is a derivative of vanillin, which is commonly used as a flavoring agent in foods and beverages. This specific compound has a hydroxy group at the para position, an iodo group at the meta position, and a methoxy group at the ortho position on a phenyl ring attached to an ethanone group. It may have potential applications in the pharmaceutical industry due to its structural features and functional groups, although further research is needed to determine its specific properties and potential uses.

Upstream product

• 498-02-2 1-(3-methoxy-4-hydroxyphenyl)ethanone 

Downstream Products

• 92287-23-5 4-Acetoxy-5-iod-3-methoxy-acetophenon 
• 3934-89-2 1-(3,4-dihydroxy-5-methoxyphenyl)-ethan-1-one 
• 245469-66-3 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)butane-1,4-dione 
• 245469-67-4 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol 
• 193739-32-1 (+/-)-cis-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 245469-68-5 2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 245469-62-9 3-(N,N-dimethylamino)-1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]propan-1-one 
• 245469-65-2 1-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-iodophenyl]prop-2-en-1-one 
• 193739-32-1 (+/-)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-cyanophenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 
• 670749-33-4 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-3-(carboethoxy)-butane-1,4-dione 
• 670749-34-5 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-butane-1,4-dione 
• 670749-35-6 1-[3-methoxy-4-hydroxy-5-iodophenyl]-4-(3,4,5-trimethoxyphenyl)-butane-1,4-diol 
• 144978-69-8 2-bromo-1-[3-methoxy-4-hydroxy-5-iodophenyl]ethanone 
• 245469-58-3 ethanone-1-[3-methoxy-4-(2-bromoethoxy)-5-iodophenyl] 

Relevant articles and documents

Efficient and sustainable laccase-catalyzed iodination of: P -substituted phenols using KI as iodine source and aerial O2 as oxidant

The laccase-catalyzed iodination of p-hydroxyarylcarbonyl- and p-hydroxyarylcarboxylic acid derivatives using KI as iodine source and aerial oxygen as the oxidant delivers the corresponding iodophenols in a highly efficient and sustainable manner with yields up to 93% on a preparative scale under mild reaction conditions.

PHARMACEUTICAL FORMULATIONS USEFUL TO TREAT INFLAMMATORY AND IMMUNE DISORDERS

A pharmaceutical formulation is provided for the treatment of inflammatory and/or immune disorders, particularly those mediated by platelet activating factor (“PAF”) or a product of 5-lipoxygenase. The formulation, in one embodiment, is an essentially anhydrous ointment containing an active agent selected from the group consisting of 2,5-diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines, and an enhancer composition containing one or more C3-18 esters such as diethyl succinate, propylene carbonate, diisopropyl adipate and glyceryl triacetate. In another embodiment, the formulation is a cream, gel, lotion, oil, or the like, containing the: active agent in crystalline form. The invention also encompasses the novel crystalline form of the active agent, and methods for using the formulations to treat individuals with inflammatory and/or immune disorders. Also encompassed is use of isopropyl alcohol (IPA) to enhance stability of the active agent and pharmaceutical formulations.

(±)-Trans-2-[3-methoxy-4-(4-chlorophenyl thioethoxy)-5-cyanophenyl]-5- (3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent PAF-receptor antagonist

The synthesis of (±)-trans-2-[3-methoxy-4- (chlorophenylthioethoxyphenyl)-5-cyanophenyl]-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran from commercially available acetovanillone and 3,4,5-trimethoxybenzaldehyde is described.