Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1034473-12-5

exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1034473-12-5 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier
  • 1034473-12-5 Structure

  • Basic information

    1. Product Name: exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane
    2. Synonyms: exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane
    3. CAS NO:1034473-12-5
    4. Molecular Formula:
    5. Molecular Weight: 286.201
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1034473-12-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane(CAS DataBase Reference)
    10. NIST Chemistry Reference: exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane(1034473-12-5)
    11. EPA Substance Registry System: exo-(1S,5S,6S)-1-(3,4-dichlorophenyl)-6-[(ethyloxy)methyl]-3-azabicyclo[3.1.0]hexane(1034473-12-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1034473-12-5(Hazardous Substances Data)

1034473-12-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1034473-12-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,4,7 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1034473-12:
(9*1)+(8*0)+(7*3)+(6*4)+(5*4)+(4*7)+(3*3)+(2*1)+(1*2)=115
115 % 10 = 5
So 1034473-12-5 is a valid CAS Registry Number.

1034473-12-5Upstream product

1034473-12-5Downstream Products

1034473-12-5Relevant articles and documents

1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanesand6-(aryl) -6-[alkoxyalkyl]-3azabicyclo[3.1.0]hexanes: A new series of potent and selective triple reuptake inhibitors

Micheli, Fabrizio,Cavanni, Paolo,Arban, Roberto,Benedetti, Roberto,Bertani, Barbara,Bettati, Michela,Bettelini, Letizia,Bonanomi, Giorgio,Braggio, Simone,Checchia, Anna,Davalli, Silvia,Fabio, Romano Di,Fazzolari, Elettra,Fontana, Stefano,Marchioro, Carla,Minick, Doug,Negri, Michele,Oliosi, Beatrice,Read, Kevin D.,Sartori, Ilaria,Tedesco, Giovanna,Tarsi, Luca,Terreni, Silvia,Visentini, Filippo,Zocchi, Alessandro,Zonzin, Laura

, p. 2534 - 2551 (2010)

The discovery of new highly potent and selective triple reuptake inhibitors is reported. The new classes of 1-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0] hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes are described together with detailed SAR. Appropriate decoration of the scaffolds was achieved with the help of a triple reuptake inhibitor pharmacophore model detailed here. Selected derivatives showed good oral bioavailability ( > 30%) and brain penetration (B/B > 4) in rats associated with high in vitro potency and selectivity at SERT, NET, and DAT. Among these compounds, microdialysis and in vivo experiments confirm that derivative 15 has an appropriate developability profile to be considered for further progression.

AZABICYCLIC COMPOUNDS AS SEROTONINE, DOPAMINE AND NOREPINEPHRINE RE-UPTAKE INHIBITORS

-

Page/Page column 81-82, (2008/12/06)

The present invention relates to novel compounds of Formula (I)' or pharmaceutically acceptable salts or a solvates thereof: wherein A is and K is a mono or bicyclic aryl group; R1 is selected from a group consisting of: halogen, C1-4alkyl and C1-4alkoxy, and such R1 may assume different meanings on the basis of p value; p is an integer from 0 to 5; R2 is a group P wherein P is and R3 is hydrogen, C1-4alkyl, C3-6cycloalkyl, C3-6cycloalkylC1-3alkyl, haloC1-2alkyl or an optionally substituted phenyl group; X is oxygen, -NR8- or sulphur; n is 0 or 1; R7 is hydrogen or methyl; R4 is hydrogen or methyl; R5 is hydrogen or C1-4alkyl; R6 is hydrogen or C1-4alkyl; and R8 is hydrogen or C1-4alkyl; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as serotonin (5-HT), dopamine (DA) and norepinephrine (NE), re-uptake inhibitors.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1034473-12-5