1034760-22-9Relevant articles and documents
Synthesis of 2,4-disubstituted isoquinolin-1(2H)-ones based on reactions of α-substituted 2-lithio-β-methoxystyrenes with isocyanates
Kobayashi, Kazuhiro,Hayashi, Kazutaka,Nam, Changeng,Fukamachi, Shuhei,Konishi, Hisatoshi
, p. 1225 - 1231 (2008/12/20)
An efficient method for the preparation of 2,4-disubstituted isoquinolin-1(2H)-ones is described. The reaction of α-substituted 2-lithio-β-methoxystyrenes, generated by treating α-substituted 2-bromo-β-methoxystyrenes with butyilithium, with isocyanates yields the corresponding α-substituted 2-(2-methoxyvinyl)benzamide derivatives, which in turn are transformed into 2,4-disubstituted isoquinolin-1(2H)-ones on treatment with a catalytic amount of concentrated hydriodic acid.