103478-12-2

Basic information

• Product Name: BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE
• Synonyms: BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE;(S)-3-(Cbz-aMino)-2-oxoazepane;(S)-3-BenzyloxycarbonylaMino-2-azepanone, 97%;Benzyl (2-Oxo-3-Azepanyl)CarbaMate;(S)-BENZYL (2-OXOAZEPAN-3-YL)CARBAMATE;L-α-[(Benzyloxycarbonyl)amino]-ε-caprolactam;(R)-benzyl (2-oxoazepan-3-yl)carbamate
• CAS NO: 103478-12-2
• Molecular Formula: C₁₄H₁₈N₂O₃
• Molecular Weight: 262.3
• Mol File: 103478-12-2.mol

Chemical Properties

• Melting Point: 116 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 510.1±49.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.84±0.20(Predicted)
• CAS DataBase Reference: BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE(103478-12-2)
• EPA Substance Registry System: BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE(103478-12-2)

Safety Data

• Hazardous Substances Data: 103478-12-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE is used as a prodrug for its ability to be converted into an active drug in the body, offering a promising avenue for drug development and delivery.
Used in Drug Delivery Systems:
In the field of drug delivery, BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE is utilized to enhance the efficiency and targeting of pharmaceutical agents, potentially improving treatment outcomes and patient compliance.
Used in Development of New Pharmaceuticals:
BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE serves as a chemical building block in the creation of new pharmaceuticals, contributing to the advancement of medical treatments and therapies.
Used as an Anticonvulsant Agent:
BENZYL (S)-(2-OXOAZEPAN-3-YL)CARBAMATE is studied for its potential as an anticonvulsant, which could be instrumental in managing conditions such as epilepsy and other seizure disorders.
Used as an Analgesic Agent:
It is also being investigated for its analgesic properties, suggesting a possible use in pain management and relief, which could benefit patients suffering from various types of pain conditions.

Upstream product

• 501-53-1 benzyl chloroformate 
• 26081-03-8 (S)-3-aminocaprolactam hydrochloride 
• 70671-54-4 N^α-carbobenzoxy-D-lysine 
• 612844-01-6 (R)-6-Azido-2-benzyloxycarbonylamino-hexanoic acid 
• 21568-87-6 2-aminocaprolactam 

Downstream Products

• 307345-56-8 (3S)-3-benzyloxycarbonylamino-1-diaminophosphoryl-2-perhydroazepinone 

Relevant articles and documents

Rapid and Mild Lactamization Using Highly Electrophilic Triphosgene in a Microflow Reactor

Lactams are cyclic amides that are indispensable as drugs and as drug candidates. Conventional lactamization includes acid-mediated and coupling-agent-mediated approaches that suffer from narrow substrate scope, much waste, and/or high cost. Inexpensive, less-wasteful approaches mediated by highly electrophilic reagents are attractive, but there is an imminent risk of side reactions. Herein, a methods using highly electrophilic triphosgene in a microflow reactor that accomplishes rapid (0.5–10 s), mild, inexpensive, and less-wasteful lactamization are described. Methods A and B, which use N-methylmorpholine and N-methylimidazole, respectively, were developed. Various lactams and a cyclic peptide containing acid- and/or heat-labile functional groups were synthesized in good to high yields without the need for tedious purification. Undesired reactions were successfully suppressed, and the risk of handling triphosgene was minimized by the use of microflow technology.

Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors

The structure of sulphostin (1), a novel dipeptidyl peptidase IV (DPP-IV) inhibitor, is consisted of three key functional groups, including a characteristic amino(sulfoamino)phosphinyl group, on a piperidine ring. To examine the relationship between its s

Intramolecular Staudinger ligation: A powerful ring-closure method to form medium-sized lactams

Efficient access to medium-sized lactams from co-amino acids that are resistant to ring-closure by traditional strategies is enabled by an intramolecular Staudinger ligation approach. An undesired premature Staudinger reaction is avoided by protecting the phosphane-containing auxiliary as a borane complex (see scheme; dabco = 1,4-diazabicyclo[2.2.2]octane).

SULPHOSTIN ANALOGUES AND PROCESSES FOR THE PREPARATION OF SULPHOSTIN AND ANALOGUES THEREOF

A sulphostin analogue represented by the general formula, wherein n is an integer of from 0 to 3, provided that a case where n is 2 and steric configurations of C* and P* are S and R, respeetively, is excluded, or a pharmaceutically acceptable salt thereof.