1034820-79-5Relevant academic research and scientific papers
Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses
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Page/Page column 4; sheet 4, (2008/12/07)
Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an in
Detection of intact influenza viruses using biotinylated biantennary S-sialosides
Kale, Ramesh R.,Mukundan, Harshini,Price, Dominique N.,Harris, J. Foster,Lewallen, Daniel M.,Swanson, Basil I.,Schmidt, Jurgen G.,Iyer, Suri S.
supporting information; body text, p. 8169 - 8171 (2009/02/02)
We report the modular synthesis of robust, biotinylated biantennary sialylglycoconjugates and their ability to differentiate between two type A influenza strains. This is the first demonstration of glycoconjugate-based discriminatory capture and detection of two strains of intact influenza virus, in the presence of the innate enzymatic activity of viral neuraminidases. We also demonstrate a carboassay using glycoconjugates as capture and reporter elements, which therefore, does not require antibodies. The capture of intact influenza viruses is of potential benefit for clinical diagnostics. Copyright
