1034840-86-2Relevant academic research and scientific papers
Improving the developability profile of pyrrolidine progesterone receptor partial agonists
Kallander, Lara S.,Washburn, David G.,Hoang, Tram H.,Frazee, James S.,Stoy, Patrick,Johnson, Latisha,Lu, Qing,Hammond, Marlys,Barton, Linda S.,Patterson, Jaclyn R.,Azzarano, Leonard M.,Nagilla, Rakesh,Madauss, Kevin P.,Williams, Shawn P.,Stewart, Eugene L.,Duraiswami, Chaya,Grygielko, Eugene T.,Xu, Xiaoping,Laping, Nicholas J.,Bray, Jeffrey D.,Thompson, Scott K.
scheme or table, p. 371 - 374 (2010/04/24)
The previously reported pyrrolidine class of progesterone receptor partial agonists demonstrated excellent potency but suffered from serious liabilities including hERG blockade and high volume of distribution in the rat. The basic pyrrolidine amine was in
PYRROLIDINANILINES
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Page/Page column 48, (2008/12/06)
The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof where R1, R2, X, and y are defined herein. Compounds of the present invention are useful as progesterone receptor modulators.
