1035262-89-5 Usage
Uses
Used in Pharmaceutical Industry:
Methyl 2-(4-chloro-3-fluorophenyl)acetate is used as a key intermediate in the synthesis of cyclopenta[d]pyrimidine derivatives, which are known as Akt protein kinase inhibitors. These inhibitors play a crucial role in the development of targeted therapies for various diseases, including cancer, by modulating the activity of the Akt protein kinase, a critical signaling molecule involved in cell survival and growth.
In the preparation of these cyclopenta[d]pyrimidine derivatives, methyl 2-(4-chloro-3-fluorophenyl)acetate serves as a building block that contributes to the overall structure and biological activity of the final compound. Its unique combination of chlorine and fluorine atoms on the phenyl ring allows for the fine-tuning of the compound's properties, such as lipophilicity and binding affinity, which are essential for the effectiveness of the resulting Akt inhibitors.
Check Digit Verification of cas no
The CAS Registry Mumber 1035262-89-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,2,6 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1035262-89:
(9*1)+(8*0)+(7*3)+(6*5)+(5*2)+(4*6)+(3*2)+(2*8)+(1*9)=125
125 % 10 = 5
So 1035262-89-5 is a valid CAS Registry Number.
1035262-89-5Relevant academic research and scientific papers
PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE
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Paragraph 0555-0556; 0489-0490, (2021/09/26)
The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof, or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatmen
