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1035374-20-9 Usage


3-Aminocyclobutanone hydrochloride is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is a white crystalline solid with the chemical formula C4H7NO.HCl and is known for its reactivity in chemical reactions, making it a valuable building block in the pharmaceutical industry.


Used in Pharmaceutical Industry:
3-Aminocyclobutanone hydrochloride is used as a synthetic intermediate for the preparation of aminocyclopentenyland aminocyclobutylphosphinic acids. These compounds act as γ-aminobutyric acid (GABA) ρ1 receptor antagonists, which are important in the development of medications targeting neurological disorders.
Additionally, 3-Aminocyclobutanone hydrochloride is used as a synthetic intermediate for the preparation of pyrrolopyrazine derivatives. These derivatives are selective spleen tyrosine kinase (Syk) inhibitors, which have potential applications in the treatment of autoimmune diseases and inflammatory conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1035374-20-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,3,7 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1035374-20:
119 % 10 = 9
So 1035374-20-9 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name 3-aminocyclobutan-1-one,hydrochloride

1.2 Other means of identification

Product number -
Other names 3-aminocyclobutan-1-one hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1035374-20-9 SDS

1035374-20-9Relevant articles and documents

Truce–Smiles Rearrangements by Strain Release: Harnessing Primary Alkyl Radicals for Metal-Free Arylation

Whalley, David M.,Seayad, Jayasree,Greaney, Michael F.

, p. 22219 - 22223 (2021/09/09)

The ring-opening of 3-aminocyclobutanone oximes enables easy generation of primary alkyl radicals, capable of undergoing an unprecedented strain-release, desulfonylative radical Truce–Smiles rearrangement, providing divergent access to valuable 1,3 diamin



Page/Page column 78, (2013/08/15)

The invention provides novel compounds having the general formula(I) wherein A, R1 and R2 are as described herein, compositions including the compounds and use of the compounds for inhibiting angiogenesis by inhibition of MAP4K4.

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