1035448-53-3Relevant academic research and scientific papers
Applicability of methyl 2,3,4-tri-O-benzoyl-1-methanesulfonyl-α-d-glucopyranuronate as a novel quaternary glucuronyl reagent for tertiary amines
Araya, Ichiro,Akita, Hiroyuki
, p. 1213 - 1223 (2008/12/20)
Applicability of a methyl 2,3,4-tri-O-benzoyl-1-methanesulfonyl-α-D-glucopyranuronate 3 as a novel quaternary glucuronyl reagent was investigated. The reaction of 3 with an aromatic tertiary amines such as pyridine derivatives or imidazole derivatives proceeded to give quaternary N-glucuronides in a moderate yields, but the reaction of 3 with an aliphatic tertiary amine did not occur. In case of the reaction of 3 with nicotine which has aromatic and aliphatic tertiary amines in the molecule, the reaction proceeded selectively on the pyridine ring to give the corresponding N-glucuronide. The present reagent was considered to be useful for the formation of N-quaternary glucuronide from aromatic tertiary amines.
