103545-98-8

Upstream product

• 198996-89-3 5,5-Diethoxy-2-isopropyl-2-phenyl-pentanenitrile 
• 5558-29-2 3-methyl-2-phenyl-butyronitrile 
• 140-29-4 phenylacetonitrile 
• 35573-93-4 3-chloro-1,1-diethoxy-propane 

Downstream Products

• 103523-56-4 α-isopropyl-α-<3-<<3-(2-methoxyphenoxy)propyl>amino>propyl>benzeneacetonitrile 
• 256943-67-6 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-(2-hydroxyethyl)piperazine 
• 552336-62-6 5-(4-benzyl-piperazin-1-yl)-2-isopropyl-2-phenyl-pentanenitrile 
• 350985-61-4 4-(4-cyano-5-methyl-4-phenylhexyl)piperazine 
• 256944-03-3 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-(2-chloroethyl) piperazine 
• 255847-08-6 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(4-chlorophenoxy)ethyl]piperazine 
• 255847-14-4 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(4-aminophenoxy)ethyl]piperazine 
• 255847-23-5 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(4-fluorophenylamino)ethyl]piperazine 
• 255847-27-9 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(benzylamino)ethyl]piperazine 
• 255847-35-9 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(4-fluorophenylaminocarbonyl)ethyl]piperazine 
• 255847-37-1 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[N-(4-fluorophenyl)carbamoylmethyl]piperazine 
• 255847-46-2 1-[(4-cyano-5-methyl-4-phenyl)hexyl]-4-[2-(2-benzylphenoxy)ethyl]piperazine 

Relevant academic research and scientific papers

Discovery of novel neuronal voltage-dependent calcium channel blockers based on emopamil left hand as a bioactive template

A series of novel neuronal voltage-dependent calcium channel (VDCC) blockers, with inhibitory activity at low micromolar and moderate solubility in water, was discovered by constructing and screening a focused library based on emopamil (1) left hand (ELH)

Novel N-substituted alpha aminoacid amides as calcium channel modulators

The compounds of formula I and derivatives thereof have been found to be active in tests that show modulation of voltage-dependent calcium channels, and are thus indicated for use in the treatment of diseases in which such modulation is beneficial, in par