1035622-06-0Relevant academic research and scientific papers
Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment
Evans, David A.,Burch, Jason D.,Hu, Essa,Jaeschke, Georg
, p. 4671 - 4699 (2008/09/21)
The enantioselective total synthesis of callipeltoside A is described. Two syntheses of the macrolactone subunit are included: the first relies upon an Ireland-Claisen rearrangement to generate the trisubstituted olefin geometry and the second utilizes an enantioselective vinylogous aldol reaction for this purpose. Enantioselective syntheses of the sugar and chlorocyclopropane side chain fragments are also disclosed. The relative and absolute stereochemistry of this natural product was determined by fragment coupling with the two enantiomers of the side chain fragment.
