1035690-22-2

Basic information

• Product Name: 1-bromo-3-cyclopropoxybenzene
• Synonyms: 1-bromo-3-cyclopropoxybenzene;1-bromo-3-(cyclopropyloxy)benzene
• CAS NO: 1035690-22-2
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213
• Mol File: 1035690-22-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 251.6±13.0 °C(Predicted)
• Appearance: /
• Density: 1.533±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-bromo-3-cyclopropoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-3-cyclopropoxybenzene(1035690-22-2)
• EPA Substance Registry System: 1-bromo-3-cyclopropoxybenzene(1035690-22-2)

Safety Data

• Hazardous Substances Data: 1035690-22-2(Hazardous Substances Data)

Usage

General Description

1-bromo-3-cyclopropoxybenzene is a chemical compound with the molecular formula C9H11BrO. It is an aromatic haloether that is commonly used as an intermediate in organic synthesis. The compound has a cyclopropoxy group attached to the benzene ring, as well as a bromine atom in the para position. 1-bromo-3-cyclopropoxybenzene is often used in the research and development of pharmaceuticals and agrochemicals. Additionally, it is used as a building block in the production of various organic compounds. 1-bromo-3-cyclopropoxybenzene is a flammable liquid with a faint, sweetish odor, and it should be handled and stored with caution due to its hazardous nature.

Upstream product

• 591-20-8 3-Bromophenol 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 1035690-24-4 2-(3-cyclopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1142227-97-1 methyl 3'-(cyclopropyloxy)-2-(2,2-dimethylcyclopentyI)-1,1'-biphenyl-4-carboxylate 
• 1142227-99-3 (3'-(cyclopropyloxy)-2-(2,2-dimethylcyclopentyI)-1,1'-biphenyl-4-yl)methanol 
• 1119090-83-3 tert-butyl 2-(6-(3-cyclopropoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoate 
• 1119090-55-9 methyl 2-(2-(3-cyclopropoxyphenyl)pyrimidin-5-ylamino)-5-cyclopropylbenzoate 
• 1119086-36-0 2-(6-(3-cyclopropoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acid 
• 808140-97-8 (3-cyclopropoxyphenyl)boronic acid 

Relevant articles and documents

Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal-mediated couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated oxidative cyclization. Optimization of the subseries containing 3,5-disubstituted furo[3,2-b]pyridines afforded potent, cell-active, and highly selective inhibitors of CLKs. Profiling of the kinase-inactive subset of 3,5,7-trisubstituted furo[3,2-b]pyridines revealed sub-micromolar modulators of the Hedgehog pathway.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

ANTIMITOTIC AMIDES FOR THE TREATMENT OF CANCER AND PROLIFERATIVE DISORDERS

Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R5, R6, R8, R9, R11, X1, and X2 are as defined herein, as compounds for treatment and prevention of cancer and proliferative diseases and disorders.